Glutathione peroxidase 2 expression in human tumors: a tissue microarray study on 18,555 tumors - Takeaways - MDSpire

Glutathione peroxidase 2 expression in human tumors: a tissue microarray study on 18,555 tumors

  • By

  • Viktoria Chirico

  • Niklas Jahn

  • Seyma Büyücek

  • Nina Schraps

  • Maximilian Lennartz

  • Katharina Möller

  • Elena Bady

  • Lisa Hornsteiner

  • Henning Plage

  • Claudia Hube-Magg

  • Martina Kluth

  • Frank Jacobsen

  • Florian Viehweger

  • David Dum

  • Andrea Hinsch

  • Christoph Fraune

  • Christian Bernreuther

  • Patrick Lebok

  • Guido Sauter

  • Till S Clauditz

  • Till Krech

  • Andreas H Marx

  • Ronald Simon

  • Eike Burandt

  • Natalia Gorbokon

  • Sarah Minner

  • Stefan Steurer

  • May 4, 2026

  • 0 min

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  • 1

    GPX2 plays a crucial role in removing reactive oxygen species from cells and is expressed in various human tumors.

  • 2

    Analysis of 18,555 tumor samples revealed GPX2 expression in 95 of 148 tumor categories, with strong positivity in several cancer types.

  • 3

    Colorectal adenocarcinomas and adenomas showed the highest GPX2 positivity, while sarcomas and lymphomas exhibited infrequent expression.

  • 4

    Reduced GPX2 staining correlates with aggressive disease features, including advanced stage and nodal metastasis in colorectal and urothelial carcinomas.

  • 5

    The study highlights the potential clinical significance of GPX2 expression in cancer, warranting further investigation across various tumor types.

Original Source(s)

Glutathione peroxidase 2 expression in human tumors: a tissue microarray study on 18,555 tumors

  • by Viktoria Chirico, Niklas Jahn, Seyma Büyücek, Nina Schraps, Maximilian Lennartz, Katharina Möller, Elena Bady, Lisa Hornsteiner, Henning Plage, Claudia Hube-Magg, Martina Kluth, Frank Jacobsen, Florian Viehweger, David Dum, Andrea Hinsch, Christoph Fraune, Christian Bernreuther, Patrick Lebok, Guido Sauter, Till S Clauditz, Till Krech, Andreas H Marx, Ronald Simon, Eike Burandt, Natalia Gorbokon, Sarah Minner, Stefan Steurer

  • May 4, 2026

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