Adolescent “Lean PCOS” Is Characterized by Higher Insulin Resistance and Adverse Adipokine Profile - Takeaways - MDSpire
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Lean PCOS in Adolescents Exhibits Elevated Insulin Resistance and Detrimental Adipokine Profiles

  • By

  • Rachel C Whooten

  • Sheryl L Rifas-Shiman

  • Izzuddin M Aris

  • Wei Perng

  • Jorge E Chavarro

  • Emily Oken

  • Marie-France Hivert

  • December 8, 2025

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  • 1

    Lean adolescents with PCOS exhibit significantly higher insulin resistance compared to their peers without PCOS.

  • 2

    The study found that lean PCOS adolescents have a lower adiponectin-leptin ratio, indicating adipose tissue dysfunction.

  • 3

    Among participants with BMI <85th percentile, those with PCOS had an earlier age at peak height velocity.

  • 4

    No significant differences in adiposity measures were observed between PCOS and non-PCOS groups within either BMI category.

  • 5

    The findings highlight the need for awareness of metabolic dysfunction in adolescents with lean PCOS.

Original Source(s)

Adolescent “Lean PCOS” Is Characterized by Higher Insulin Resistance and Adverse Adipokine Profile

  • by Rachel C Whooten, Sheryl L Rifas-Shiman, Izzuddin M Aris, Wei Perng, Jorge E Chavarro, Emily Oken, Marie-France Hivert

  • December 8, 2025

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