Non-invasive assessment of glymphatic dysfunction in middle cerebral artery stenosis based on DTI-ALPS and ro-ALPS - Takeaways - MDSpire

Non-invasive assessment of glymphatic dysfunction in middle cerebral artery stenosis based on DTI-ALPS and ro-ALPS

  • By

  • Yidi Zhu

  • Luoyu Wang

  • Liqing Zhang

  • Xue Tang

  • Maoling Liu

  • Qingqing Wen

  • Darong Zhu

  • Han Zhang

  • Xiufang Xu

  • Zhongxiang Ding

  • June 17, 2026

  • 0 min

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  • 1

    The study evaluated glymphatic function in middle cerebral artery stenosis (MCA-S) using DTI-ALPS and ro-ALPS techniques.

  • 2

    Both DTI-ALPS and ro-ALPS indices were significantly lower in MCA-S patients compared to healthy controls (p < 0.001).

  • 3

    In MCA-S patients, the DTI-ALPS index negatively correlated with choroid plexus volume (r = −0.541, pFDR = 0.012).

  • 4

    The ro-ALPS index also showed a negative correlation with choroid plexus volume (r = −0.568, pFDR < 0.001).

  • 5

    These findings indicate impaired perivascular clearance in MCA-S patients, suggesting potential utility of ALPS indices as imaging biomarkers.

Original Source(s)

Non-invasive assessment of glymphatic dysfunction in middle cerebral artery stenosis based on DTI-ALPS and ro-ALPS

  • by Yidi Zhu, Luoyu Wang, Liqing Zhang, Xue Tang, Maoling Liu, Qingqing Wen, Darong Zhu, Han Zhang, Xiufang Xu, Zhongxiang Ding

  • June 17, 2026

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