Rapid laboratory identification of fibrinogen Longmont: a case report and literature review - Takeaways - MDSpire

Rapid laboratory identification of fibrinogen Longmont: a case report and literature review

  • By

  • Cuihua Ma

  • Xuezhuo Li

  • Da Yin

  • Huidong Ma

  • Wenran Lu

  • Chunhua Wang

  • June 22, 2026

  • 0 min

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  • 1

    A patient with unstable angina exhibited abnormally low fibrinogen levels during preoperative screening, inconsistent with clinical symptoms.

  • 2

    Optical fibrinogen assays reported falsely low results, while magnetic bead assays provided normal fibrinogen levels in the same patient.

  • 3

    Fibrinogen Longmont is characterized by a genetic mutation that impairs clot formation, leading to discrepancies in laboratory test results.

  • 4

    The study emphasizes the importance of using multiple methodologies for accurate fibrinogen assessment to avoid misdiagnosis.

  • 5

    Laboratory findings suggest that optical methods may fail due to signal loss, necessitating alternative testing approaches for accurate diagnosis.

Original Source(s)

Rapid laboratory identification of fibrinogen Longmont: a case report and literature review

  • by Cuihua Ma, Xuezhuo Li, Da Yin, Huidong Ma, Wenran Lu, Chunhua Wang

  • June 22, 2026

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