Jiangzhi ruanmai recipe alleviates atherosclerosis in ApoE−/− mice by regulating cholesterol metabolism involved in gut microbiota remodeling - Takeaways - MDSpire

Jiangzhi ruanmai recipe alleviates atherosclerosis in ApoE−/− mice by regulating cholesterol metabolism involved in gut microbiota remodeling

  • By

  • Guinan Xie

  • Lijun Zhang

  • An Yan

  • Guiyun Pan

  • Yudie Xu

  • Zhihui Song

  • Liping Guo

  • Yi Wang

  • May 29, 2026

  • 0 min

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  • 1

    Jiangzhi Ruanmai Formula (JZRM) mitigates atherosclerosis in ApoE−/− mice by modulating cholesterol metabolism through gut microbiota alterations.

  • 2

    JZRM significantly reduced lipid, glucose, and inflammation levels, as well as aortic plaque area in mice fed a high-fat diet.

  • 3

    The formula increased the abundance and diversity of intestinal flora, enhancing bacteria that promote bile acid decomposition and excretion.

  • 4

    JZRM upregulated key proteins and genes involved in reverse cholesterol transport and bile acid synthesis, promoting cholesterol metabolism.

  • 5

    The study highlights JZRM's potential as a therapeutic agent for atherosclerosis by regulating the gut microbiota-liver-cholesterol axis.

Original Source(s)

Jiangzhi ruanmai recipe alleviates atherosclerosis in ApoE−/− mice by regulating cholesterol metabolism involved in gut microbiota remodeling

  • by Guinan Xie, Lijun Zhang, An Yan, Guiyun Pan, Yudie Xu, Zhihui Song, Liping Guo, Yi Wang

  • May 29, 2026

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