Baihe Gujin decoction ameliorates sepsis-induced acute lung injury through Nrf2/GPX4-mediated antioxidant defense and PPARα-driven metabolic reprogramming: a multi-omics investigation - Takeaways - MDSpire

Baihe Gujin decoction ameliorates sepsis-induced acute lung injury through Nrf2/GPX4-mediated antioxidant defense and PPARα-driven metabolic reprogramming: a multi-omics investigation

  • By

  • Kaiyuan Zhang

  • Yuqing Huang

  • Yuan Wu

  • Zhitao Yang

  • Fangyu Luo

  • Yu Han

  • Lan Zheng

  • Lingling Lv

  • June 29, 2026

  • 0 min

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  • 1

    Baihe Gujin decoction (BHGJD) shows protective effects against sepsis-induced acute lung injury (ALI) in a cecal ligation and puncture mouse model.

  • 2

    BHGJD activates the Nrf2/GPX4 antioxidant response, reducing lipid peroxidation and restoring mitochondrial homeostasis.

  • 3

    The decoction promotes PPARα/CPT1A-mediated metabolic reprogramming towards fatty acid utilization, enhancing mitochondrial respiration.

  • 4

    BHGJD reduces inflammatory lipid mediators, contributing to its protective effects against sepsis-induced ALI.

  • 5

    The study integrates multi-omics analysis to elucidate the mechanisms underlying BHGJD's protective actions in sepsis-induced ALI.

Original Source(s)

Baihe Gujin decoction ameliorates sepsis-induced acute lung injury through Nrf2/GPX4-mediated antioxidant defense and PPARα-driven metabolic reprogramming: a multi-omics investigation

  • by Kaiyuan Zhang, Yuqing Huang, Yuan Wu, Zhitao Yang, Fangyu Luo, Yu Han, Lan Zheng, Lingling Lv

  • June 29, 2026

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