Serotonergic antidepressants are associated with increased bleeding events within 30-days after total shoulder arthroplasty: a propensity-matched analysis of 54,291 patients - Takeaways - MDSpire

Serotonergic antidepressants are associated with increased bleeding events within 30-days after total shoulder arthroplasty: a propensity-matched analysis of 54,291 patients

  • By

  • John T. Strony

  • Andrew J. Moyal

  • Jeremy M. Adelstein

  • Robert J. Burkhart

  • Anthony M. Imbrogno

  • Rayyan Abid

  • Robert J. Gillespie

  • Raymond E. Chen

  • March 12, 2026

  • 0 min

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  • 1

    Total shoulder arthroplasty (TSA) is increasingly performed to treat various shoulder pathologies in the United States.

  • 2

    Serotonergic antidepressants, including SSRIs and SNRIs, are linked to increased bleeding risks due to impaired platelet aggregation.

  • 3

    This study analyzed 54,291 TSA patients to assess the impact of serotonergic antidepressants on postoperative outcomes.

  • 4

    Cohort 1 included 7,660 patients on SSRIs or SNRIs, while Cohort 2 had 43,631 patients without such medications.

  • 5

    The primary outcome focused on bleeding events, including post-hemorrhagic anemia and transfusions, following TSA.

Original Source(s)

Serotonergic antidepressants are associated with increased bleeding events within 30-days after total shoulder arthroplasty: a propensity-matched analysis of 54,291 patients

  • by John T. Strony, Andrew J. Moyal, Jeremy M. Adelstein, Robert J. Burkhart, Anthony M. Imbrogno, Rayyan Abid, Robert J. Gillespie, Raymond E. Chen

  • March 12, 2026

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