Risk factors for disease generalization in acetylcholine receptor antibody-positive ocular myasthenia: a multicenter retrospective study - Takeaways - MDSpire

Risk factors for disease generalization in acetylcholine receptor antibody-positive ocular myasthenia: a multicenter retrospective study

  • By

  • Lorenzo Verriello

  • Roberto Sartor

  • Fabrizio Bellizzi

  • Chiara Dalla Torre

  • Maria Elena Pessa

  • Marco Belluzzo

  • Alessio Bratina

  • Magda Quagliotto

  • Chiara Rosa Mancinelli

  • Michele Rana

  • Fulvio Pasquin

  • Martina Fabris

  • Giada Pauletto

  • Miriam Isola

  • Maria De Martino

  • Paolo Manganotti

  • Mariarosaria Valente

  • May 25, 2026

  • 0 min

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  • 1

    The study identified risk factors for secondary generalization in ocular-onset myasthenia gravis patients with anti-AChR antibodies.

  • 2

    Among 85 patients, 47.1% developed generalized myasthenia gravis during follow-up.

  • 3

    Higher anti-AChR antibody titers and abnormal facial repetitive nerve stimulation were linked to increased risk of disease progression.

  • 4

    No independent predictors of generalization were found in multivariable analysis, highlighting the complexity of disease progression.

  • 5

    The findings suggest that combined assessment of identified factors may aid in early clinical risk stratification for patients.

Original Source(s)

Risk factors for disease generalization in acetylcholine receptor antibody-positive ocular myasthenia: a multicenter retrospective study

  • by Lorenzo Verriello, Roberto Sartor, Fabrizio Bellizzi, Chiara Dalla Torre, Maria Elena Pessa, Marco Belluzzo, Alessio Bratina, Magda Quagliotto, Chiara Rosa Mancinelli, Michele Rana, Fulvio Pasquin, Martina Fabris, Giada Pauletto, Miriam Isola, Maria De Martino, Paolo Manganotti, Mariarosaria Valente

  • May 25, 2026

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