Do Urate Targets Influence CV Risk? - Takeaways - MDSpire
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Do Urate Targets Influence CV Risk?

Researchers examine whether achieving treat-to-target serum urate levels with urate-lowering treatment affects long-term cardiovascular outcomes in patients with gout.

  • By

  • Kathryn Wighton

  • January 30, 2026

  • 3 min

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  • 1

    Fewer than one-third of gout patients achieved serum urate targets within 12 months, impacting cardiovascular risk.

  • 2

    Achieving urate levels below 6 mg/dL was linked to a 9% relative risk reduction for major adverse cardiovascular events.

  • 3

    Patients with high cardiovascular risk saw a 23% relative risk reduction when urate levels were lowered below 5 mg/dL.

  • 4

    The study involved 109,504 adults, with a mean follow-up of 3.5 years, revealing a 14% incidence of major adverse cardiovascular events.

  • 5

    Treat-to-target therapy not only improved cardiovascular outcomes but also resulted in fewer gout flares among patients.

Original Source(s)

Do Urate Targets Influence CV Risk?

  • by Kathryn Wighton

  • January 30, 2026

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