From persistent hypercalcemia to parathyroid carcinoma: a case report of acute urinary retention and the diagnostic role of Ki-67 - Takeaways - MDSpire

From persistent hypercalcemia to parathyroid carcinoma: a case report of acute urinary retention and the diagnostic role of Ki-67

  • By

  • Chang Deng

  • Chun Huang

  • Xinliang Su

  • May 4, 2026

  • 0 min

Share

  • 1

    Parathyroid carcinoma is a rare endocrine neoplasm often misdiagnosed as benign conditions, complicating its identification and treatment.

  • 2

    A 59-year-old male presented with acute urinary retention due to severe hypercalcemia, initially misdiagnosed as benign prostatic hyperplasia.

  • 3

    The patient underwent three surgeries over four years before a definitive diagnosis of parathyroid carcinoma was confirmed, highlighting diagnostic challenges.

  • 4

    Pathological analysis revealed a Ki-67 proliferation index of 8%, indicating malignancy and emphasizing the need for careful histopathological evaluation.

  • 5

    This case underscores the importance of interdisciplinary collaboration and vigilance in diagnosing parathyroid carcinoma, especially with atypical symptoms.

Original Source(s)

From persistent hypercalcemia to parathyroid carcinoma: a case report of acute urinary retention and the diagnostic role of Ki-67

  • by Chang Deng, Chun Huang, Xinliang Su

  • May 4, 2026

Related Content

Global landscape analysis of antibody-drug conjugate clinical trials for prostatic neoplasms: current status, opportunities and challenges

Pediatric meningoencephalitis in the molecular diagnostic era: epidemiological insights from 1198 suspected cases in Germany between 2016 and 2024

Case Report: [225Ac]Ac-PSMA-617 therapy in a patient with metastatic castration-resistant prostate cancer (mCRPC) and intracranial meningioma