CAR T Before Surgery Improves Glioblastoma Control in Mice
Study finds that tumor resection creates a more immunosuppressive environment and that earlier CAR T cell treatment prolongs survival
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CAR T cell administration before glioblastoma surgery improved tumor control and survival in mouse models compared to postoperative treatment.
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Surgery-induced changes in the tumor microenvironment may hinder the effectiveness of postoperative immunotherapy.
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The study found increased TREM2 levels around the resection cavity, indicating immunosuppressive myeloid cell activity post-surgery.
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Preoperative CAR T cells maintained stronger effector function and better distribution compared to those administered during surgery.
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The Geneva research team plans to initiate a phase I trial testing CAR T cells in newly diagnosed glioblastoma patients.
