Association between homocysteine level and unexplained recurrent pregnancy loss: a meta-analysis

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Elevated homocysteine levels are significantly associated with unexplained recurrent pregnancy loss, with an odds ratio of 3.46.
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The meta-analysis included 13 case-control studies with a total of 1,473 women with uRPL and 1,605 controls.
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Subgroup analyses revealed consistent associations across geographic regions, with varying pooled odds ratios.
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Stronger associations were found in studies with homocysteine cutoffs greater than 12 μmol/L compared to lower cutoffs.
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Variations in homocysteine cutoff definitions may explain the heterogeneity observed in the study results.

Frontiers In Endocrinology

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