Ixekizumab With or Without Tirzepatide in Adults With Psoriasis and Overweight or Obesity: A Phase 3b - Takeaways - MDSpire
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Efficacy of Ixekizumab Alone or Combined with Tirzepatide in Psoriasis Patients with Overweight or Obesity: A Phase 3b Study

  • By

  • Mark Lebwohl

  • Andrew Blauvelt

  • Cynthia E. Kartman

  • Cianna Leatherwood

  • Kenneth B. Gordon

  • Naveed Sattar

  • Luis Puig

  • Joseph F. Merola

  • Kimberly Siu

  • Rona Wang

  • Luna Sun

  • Ann Leung

  • Najwa Somani

  • Maria Jose Rueda

  • Anabela Cardoso

  • Mark C. Genovese

  • April W. Armstrong

  • Bruce Strober

  • July 1, 2026

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  • 1

    Psoriasis is commonly associated with overweight or obesity, with a prevalence of 60% to 78% among affected individuals.

  • 2

    Patients with psoriasis and obesity experience poorer clinical outcomes and lower response rates to biologic treatments.

  • 3

    Ixekizumab, an interleukin 17A inhibitor, has shown robust efficacy in achieving skin clearance in psoriasis patients.

  • 4

    The TOGETHER-PsO trial evaluates the efficacy and safety of ixekizumab combined with tirzepatide in patients with moderate to severe psoriasis and obesity.

  • 5

    The primary endpoint of the trial is the simultaneous achievement of PASI 100 and at least a 10% weight reduction at week 36.

Original Source(s)

Ixekizumab With or Without Tirzepatide in Adults With Psoriasis and Overweight or Obesity: A Phase 3b

  • by Mark Lebwohl, Andrew Blauvelt, Cynthia E. Kartman, Cianna Leatherwood, Kenneth B. Gordon, Naveed Sattar, Luis Puig, Joseph F. Merola, Kimberly Siu, Rona Wang, Luna Sun, Ann Leung, Najwa Somani, Maria Jose Rueda, Anabela Cardoso, Mark C. Genovese, April W. Armstrong, Bruce Strober

  • July 1, 2026

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