Plasma pTau217 Cutoffs for Clinical Use

Researchers assess how biological factors influence plasma biomarker interpretation for amyloid detection.

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Kidney dysfunction and anemia elevate plasma pTau217 levels, affecting diagnostic classification with standard cutoffs.
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Subgroup-specific plasma pTau217 cutoffs improved diagnostic accuracy and reduced costs, especially in advanced chronic kidney disease.
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The double-cutoff strategy enhanced diagnostic accuracy in obesity but resulted in many intermediate results needing confirmatory imaging.
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Optimal cutoffs for pTau217 provided better diagnostic accuracy and economic efficiency in chronic kidney disease and anemia.
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The study's findings highlight the need for adjusted diagnostic thresholds for pTau217 to maintain precision in identifying Aβ positivity.

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