The applications of TMS in brain function assessment and treatment of mental disorders: a narrative review - Takeaways - MDSpire
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Exploring the Role of TMS in Evaluating Brain Function and Addressing Mental Health Disorders: A Comprehensive Review

  • By

  • Youyou Teng

  • Ziqi Gu

  • Ling Ding

  • Huicong Shi

  • Zhifei Gao

  • Haiyun Xu

  • July 6, 2026

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  • 1

    The FDA approved repetitive transcranial magnetic stimulation (rTMS) in 2008 for treating depression, marking a significant advancement in mental health therapies.

  • 2

    TMS is a non-invasive neuromodulation technique used to treat various mental disorders and assess brain functions through stimulation of targeted brain regions.

  • 3

    The review summarizes TMS's therapeutic effects on disorders such as depression, bipolar disorder, schizophrenia, ADHD, and autism spectrum disorder.

  • 4

    TMS mechanisms involve neurotransmitter expression, neuroinflammation, neurotrophic factor production, and processes related to brain plasticity and apoptosis.

  • 5

    Emerging applications of TMS include its combination with neuroimaging techniques to evaluate brain function and optimize treatment efficacy in mental disorders.

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