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SRSF1 Gene Delivery Extends Lifespan in Aged Mice
An RNA sequencing and machine learning screening platform identified an RNA-processing factor that reduced markers of cellular aging without erasing cell identity
Researchers identified SRSF1 through a machine learning screen designed to find genes that make aged cells more youthful while preserving cell identity.
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In human fibroblasts, SRSF1 overexpression reduced senescence, inflammatory signaling, and proteostatic stress while restoring DNA repair programs.
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In aged female mice, inducible SRSF1 delivery increased median lifespan from 778 to 886 days and reduced the rate of frailty accumulation by approximately 44%.
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SRSF1 treatment delayed the onset of sustained frailty by 123 days, and its effects depended on controlling expression timing and level.
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The findings are preclinical, come from a small mouse cohort, and the mechanisms linking SRSF1-mediated RNA processing to the observed effects remain under investigation.
