Disseminated hepatic epithelioid hemangioendothelioma with multiorgan metastases achieving long-term stability with Pazopanib: a case report

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Epithelioid Hemangioendothelioma (EHE) is a rare malignant vascular neoplasm, primarily affecting the liver and often misdiagnosed.
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A 28-year-old male patient presented with multifocal hepatic EHE and systemic symptoms, leading to a diagnosis of disseminated disease.
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Immunohistochemistry confirmed the endothelial origin of the neoplasm, with positive markers including CD31, CD34, and FLI-1.
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The patient was treated with Pazopanib, resulting in stable disease over a 4-year follow-up without significant regression or progression.
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This case highlights the diagnostic and management challenges of EHE, particularly within the Palestinian healthcare system.

Frontiers In Oncology

by Alaa Naiem Zaro, Salar Nael Sajadieh, Ansam Khaled Doudin, Salem K. Qupp, Laith Elayan, Ola Abu Laban, Marwan Qabaja, Amaal Alamleh
June 3, 2026

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