Efficacy and safety of Buyang Huanwu Decoction combined with α-lipoic acid for diabetic peripheral neuropathy: a systematic review with in-depth heterogeneity deconstruction and methodological appraisal - Takeaways - MDSpire

Efficacy and safety of Buyang Huanwu Decoction combined with α-lipoic acid for diabetic peripheral neuropathy: a systematic review with in-depth heterogeneity deconstruction and methodological appraisal

  • By

  • Qi Yong

  • Peiying Zhang

  • Yunxi Xu

  • Chao Xu

  • Hua Bai

  • Hejiang Ye

  • April 30, 2026

  • 0 min

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  • 1

    Diabetic peripheral neuropathy (DPN) affects approximately 50% of the global diabetic population, significantly impacting quality of life.

  • 2

    The combination of Buyang Huanwu Decoction (BYHWD) and α-lipoic acid (ALA) significantly improves subjective DPN symptoms.

  • 3

    Meta-analysis revealed high heterogeneity in nerve conduction velocity (NCV) results, limiting reliable quantitative conclusions.

  • 4

    Sources of heterogeneity included non-standardized NCV measurements and complex intervention-patient matching.

  • 5

    This study provides a methodological framework for addressing heterogeneity in future research on DPN treatments.

Original Source(s)

Efficacy and safety of Buyang Huanwu Decoction combined with α-lipoic acid for diabetic peripheral neuropathy: a systematic review with in-depth heterogeneity deconstruction and methodological appraisal

  • by Qi Yong, Peiying Zhang, Yunxi Xu, Chao Xu, Hua Bai, Hejiang Ye

  • April 30, 2026

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