MRI markers of glymphatic dysfunction in tuberculous meningitis: associations with CSF proteins and cognitive impairment

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The study investigates glymphatic function's role in cognitive decline among patients with tuberculous meningitis (TBM) using functional MRI.
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Imaging markers indicated that TBM patients had altered perivascular space and choroid plexus volumes compared to healthy controls.
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The ALPS index positively correlated with cognitive measures, suggesting its potential as a biomarker for cognitive dysfunction in TBM.
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CSF proteomics were analyzed, but did not mediate the relationship between glymphatic function and cognitive outcomes in TBM.
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Findings highlight the importance of glymphatic dysfunction in TBM and its association with cognitive impairment, particularly during the MCI phase.

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