T-knife Therapeutics has launched a Phase 1 trial of TK-6302, a CRISPR-engineered T cell therapy targeting PRAME-expressing solid tumors.
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The ATLAS trial will evaluate TK-6302 in patients with advanced PRAME-positive cancers and is set to begin later this year.
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TK-6302 incorporates a high-affinity receptor for PRAME and genetic modifications to enhance T cell persistence and activity in tumors.
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Preclinical studies indicated that TK-6302 effectively eliminated tumor growth and demonstrated superior anti-tumor activity compared to control cells.
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If successful, TK-6302 could broaden the application of engineered T cell therapies to solid tumors, improving outcomes in challenging cases.
