Immunogenicity, Safety, and Persistence Induced by Triple- and Standard-Strength 4-Dose Hepatitis B Vaccination Regimens in Patients Receiving Hemodialysis - Takeaways - MDSpire

Immunogenicity, Safety, and Persistence Induced by Triple- and Standard-Strength 4-Dose Hepatitis B Vaccination Regimens in Patients Receiving Hemodialysis

  • By

  • Tian Yao

  • Yandi Li

  • Yidan Zhang

  • Yangle Sun

  • Yana Guo

  • Jianmin Wang

  • Xiaohui Song

  • Wei Zhang

  • Baozhu Wei

  • Jingen Bai

  • Hui Wang

  • Weimin Yu

  • Huiyuan Wang

  • Lu Jiao

  • Yinqiang Diao

  • Liming Liu

  • Shuaishuai Shi

  • Jie Yang

  • Xiaojun Ren

  • Wenyuan Liu

  • Jingai Fang

  • Xiaofeng Liang

  • Suping Wang

  • Yongliang Feng

  • October 8, 2024

  • 0 min

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  • 1

    The study evaluated the immunogenic response, safety, and longevity of different hepatitis B vaccination regimens in hemodialysis patients.

  • 2

    A total of 504 hemodialysis patients were enrolled and randomly assigned to receive three different hepatitis B vaccine schedules.

  • 3

    The triple-strength 4-dose regimen (60 μg) demonstrated superior immunogenicity and longer duration of protective antibodies compared to standard regimens.

  • 4

    Response rates of anti-HBs decreased significantly over time, with the triple-strength group maintaining protective antibodies for 29.2 months.

  • 5

    All adverse reactions to the vaccination were mild, indicating that the triple-strength regimen is safe for hemodialysis patients.

Original Source(s)

Immunogenicity, Safety, and Persistence Induced by Triple- and Standard-Strength 4-Dose Hepatitis B Vaccination Regimens in Patients Receiving Hemodialysis

  • by Tian Yao, Yandi Li, Yidan Zhang, Yangle Sun, Yana Guo, Jianmin Wang, Xiaohui Song, Wei Zhang, Baozhu Wei, Jingen Bai, Hui Wang, Weimin Yu, Huiyuan Wang, Lu Jiao, Yinqiang Diao, Liming Liu, Shuaishuai Shi, Jie Yang, Xiaojun Ren, Wenyuan Liu, Jingai Fang, Xiaofeng Liang, Suping Wang, Yongliang Feng

  • October 8, 2024

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