Enhancement of Omicron-specific immune responses following bivalent COVID-19 booster vaccination in patients with chronic lymphocytic leukaemia

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Patients with chronic lymphocytic leukaemia (CLL) show enhanced immune responses after receiving bivalent COVID-19 booster vaccinations.
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87% of CLL patients demonstrated measurable antibody responses post-vaccination, with titres comparable to healthy controls.
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Bivalent vaccination resulted in a preferential increase in antibody responses against the Omicron BA.1 variant compared to the ancestral spike.
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Cellular immunity was robust, showing a significant increase in responses to Omicron peptides following bivalent vaccination.
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Despite improvements, neutralisation of recent Omicron subvariants remains limited, indicating a need for updated vaccines.

Blood Cancer Journal

by Thomas Roberts, Grace Uwenedi, Rachel Bruton, Graham McIlroy, Sarah Damery, Panagiota Sylla, Nicola Logan, Sam Scott, May Lau, Ahmed Elzaidi, Siobhan Plass, Soumyajit Mallick, Katie Spencer, Christine Stephens, Christopher Bentley, Guy Pratt, Jianmin Zuo, Shankara Paneesha, Brian Willett, Paul Moss, Helen Parry
January 25, 2024

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