Long non-coding RNAs as molecular hubs integrating inflammatory and osteogenic pathways in calcific aortic valve disease - Takeaways - MDSpire

Long non-coding RNAs as molecular hubs integrating inflammatory and osteogenic pathways in calcific aortic valve disease

  • By

  • Juan Ignacio Muñoz-Manco

  • Annisa Mardianing Utami

  • Zhexi Li

  • Georg Nickenig

  • Mohammed Rabiul Hosen

  • July 8, 2026

  • 0 min

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  • 1

    Calcific aortic valve disease (CAVD) is a leading cause of morbidity and mortality, particularly affecting the aging population.

  • 2

    Aortic stenosis (AS) is now recognized as an actively regulated disease involving inflammation, fibrosis, and calcification.

  • 3

    Long non-coding RNAs (lncRNAs) are emerging as critical regulators of gene expression in valvular interstitial cell biology.

  • 4

    Circulating lncRNAs may serve as novel mediators for intercellular communication and potential biomarkers in AS management.

  • 5

    Further research is needed to explore the specific roles of lncRNAs in AS and to develop effective lncRNA-based therapeutic strategies.

Original Source(s)

Long non-coding RNAs as molecular hubs integrating inflammatory and osteogenic pathways in calcific aortic valve disease

  • by Juan Ignacio Muñoz-Manco, Annisa Mardianing Utami, Zhexi Li, Georg Nickenig, Mohammed Rabiul Hosen

  • July 8, 2026

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