Epileptic Seizures Associated with Gliomas in Patients with Newly Diagnosed and Recurrent IDH-Wildtype Glioblastoma: Insights from the 2021 WHO CNS Tumor Classification - Takeaways - MDSpire

Epileptic Seizures Associated with Gliomas in Patients with Newly Diagnosed and Recurrent IDH-Wildtype Glioblastoma: Insights from the 2021 WHO CNS Tumor Classification

  • By

  • Xing Fan

  • Jianli Dai

  • Jiajia Liu

  • Gan You

  • Ke Li

  • Shengyu Fang

  • Jiahan Dong

  • Jiawei Shi

  • Jiangwei Wang

  • December 5, 2025

  • 0 min

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  • 1

    Gliomas are the most common and lethal primary CNS cancers, with glioblastomas being the majority of diagnosed cases in adults.

  • 2

    The incidence of glioma-related epilepsy (GRE) in patients ranges from 40 to 90%, influenced by tumor pathology and grade.

  • 3

    The 2021 WHO classification redefined GBM as 'GBM, IDH-wildtype', necessitating updated research on GRE characteristics.

  • 4

    A retrospective study analyzed clinical correlates of GRE in newly diagnosed and recurrent GBM, IDH-wildtype patients.

  • 5

    Postoperative seizure control was monitored, with inadequate control defined as any unprovoked seizures within one year after surgery.

Original Source(s)

Epileptic Seizures Associated with Gliomas in Patients with Newly Diagnosed and Recurrent IDH-Wildtype Glioblastoma: Insights from the 2021 WHO CNS Tumor Classification

  • by Xing Fan, Jianli Dai, Jiajia Liu, Gan You, Ke Li, Shengyu Fang, Jiahan Dong, Jiawei Shi, Jiangwei Wang

  • December 5, 2025

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