Uncommon Presentation of Onychomycosis Caused by Aspergillus niger in a Healthy Adult: A Case of Non-Dermatophyte Mold Infection - Takeaways - MDSpire

Uncommon Presentation of Onychomycosis Caused by Aspergillus niger in a Healthy Adult: A Case of Non-Dermatophyte Mold Infection

  • By

  • Sugat A. Jawade

  • Nandkishor J. Bankar

  • Sudhir P. Singh

  • Sabiha T. Quazi

  • Mayur S. Dudhe

  • Rutwik Khandeshe

  • January 22, 2026

  • 0 min

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  • 1

    Onychomycosis is a chronic fungal infection of the nails, with nondermatophyte molds (NDMs) increasingly recognized as significant causative agents.

  • 2

    NDM infections often present atypically, leading to diagnostic challenges and potential misdiagnosis due to lack of common symptoms like periungual inflammation.

  • 3

    A case report describes an immunocompetent man with onychomycosis caused by Aspergillus niger, presenting as brown discoloration without trauma or systemic illness.

  • 4

    Diagnosis of NDM onychomycosis requires clinical suspicion and confirmatory tests, including microscopy and fungal culture, to differentiate from dermatophyte infections.

  • 5

    The patient successfully treated with oral terbinafine and topical ciclopirox showed complete improvement at three months, highlighting effective management of NDM onychomycosis.

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