Immediate post-injury HMGB1 neutralization prevents synaptic dysfunction in burn and hindlimb unloaded rats - Takeaways - MDSpire

Immediate post-injury HMGB1 neutralization prevents synaptic dysfunction in burn and hindlimb unloaded rats

  • By

  • Sravan Gopalkrishna Shetty Sreenivasa Murthy

  • Gábor Törő

  • Allison Wyrick

  • Amina El Ayadi

  • Steven E. Wolf

  • Nisha J. Garg

  • Balaji Krishnan

  • Juquan Song

  • June 23, 2026

  • 0 min

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  • 1

    Severe burns and hindlimb unloading induce hyperinflammation and hippocampal synaptic dysfunction in rats.

  • 2

    Anti-HMGB1 neutralizing antibody treatment mitigates systemic inflammation and preserves hippocampal function.

  • 3

    Burned rats subjected to hindlimb unloading showed increased burn wound size and elevated inflammatory cytokines.

  • 4

    Electrophysiological analysis revealed synaptic dysfunction characterized by hyperexcitability in untreated burned rats.

  • 5

    Early reduction of HMGB1 activity protects against inflammation and restores hippocampal integrity post-injury.

Original Source(s)

Immediate post-injury HMGB1 neutralization prevents synaptic dysfunction in burn and hindlimb unloaded rats

  • by Sravan Gopalkrishna Shetty Sreenivasa Murthy, Gábor Törő, Allison Wyrick, Amina El Ayadi, Steven E. Wolf, Nisha J. Garg, Balaji Krishnan, Juquan Song

  • June 23, 2026

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