Dye-free versus dye-containing submucosal injection solutions in ESD for colorectal LST: a multi-center retrospective study on efficacy and safety - Takeaways - MDSpire

Dye-free versus dye-containing submucosal injection solutions in ESD for colorectal LST: a multi-center retrospective study on efficacy and safety

  • By

  • Qian Zhang

  • Fengcheng Zang

  • Jie Xu

  • Yunfu Feng

  • Lijun Huang

  • Zhibing Wang

  • Xiaodan Xu

  • Jian Chen

  • Luojie Liu

  • May 14, 2026

  • 0 min

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  • 1

    Colorectal laterally spreading tumors (LSTs) require timely endoscopic resection to prevent progression to invasive colorectal cancer.

  • 2

    Endoscopic submucosal dissection (ESD) is a key technique for LSTs, allowing en bloc resection and reducing local tumor recurrence risk.

  • 3

    Submucosal injection solutions are crucial for ESD, creating a cushion that protects against thermal injury and aids visualization.

  • 4

    The study compares dye-free submucosal injection solutions (DFSIs) and dye-containing solutions (DCSIs) for ESD in colorectal LSTs.

  • 5

    Preliminary findings suggest that DFSIs may simplify procedures and reduce complications while maintaining adequate visualization.

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