Primary diffuse large B-cell lymphoma of the rectus abdominis muscle: a presumed primary case report and literature review

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Primary diffuse large B-cell lymphoma (DLBCL) of the rectus abdominis muscle is an extremely rare subtype of extranodal non-Hodgkin lymphoma.
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An 85-year-old female presented with a painful mass in the right lower abdominal wall, leading to a diagnosis of primary DLBCL confirmed by biopsy.
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Imaging studies often misdiagnose primary rectus abdominis lymphoma due to non-specific clinical manifestations and imaging features.
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The patient received 4 cycles of an attenuated R-THP-COP regimen, achieving a complete radiological response after treatment.
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This case highlights the importance of accurate histopathological diagnosis for rare and aggressive lymphomas in elderly patients.

Frontiers In Oncology

by Xuejuan Duan, Xiangyong Yue, Jianlei Cao, Yadong Liu, Jun Zhang, Yuguang Shang
June 2, 2026

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