Elevated low-density lipoprotein cholesterol levels and prostate cancer risk: UK Biobank evidence

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Prostate cancer (PCa) is the second most common solid tumor in men globally, with complex associations involving hepatic function.
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Research indicates that very low low-density lipoprotein (LDL) levels may paradoxically correlate with increased PCa incidence.
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The UK Biobank study analyzed the relationship between lipid metabolism and PCa risk in a large cohort of over 500,000 participants.
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Significant associations were found between family history of PCa, health index, and PCa risk, with elevated LDL showing a protective effect.
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The study utilized multivariable Cox proportional hazards regression to assess various risk factors for PCa development.

World Journal Of Urology

by Alexa, R., Kranz, J., Thöne, M., Grundl, S., Hoffmann, M., Koop, P. H., Feng, C., Schneider, K. M., Schneider, C., Saar, M.
February 27, 2026

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