NMDA receptors are not necessary for burst firing of lateral habenula neurons in mice - Takeaways - MDSpire

NMDA receptors are not necessary for burst firing of lateral habenula neurons in mice

  • By

  • Rong Zhou

  • Jingjing Lu

  • Yunxiang Ling

  • Hong Wang

  • Lijun Cui

  • Yongliang Pan

  • Huanxin Chen

  • June 11, 2026

  • 0 min

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  • 1

    Burst firing in the lateral habenula (LHb) is enhanced under stress and depression, indicating its potential role in these conditions.

  • 2

    The study used C57BL/6J male mice to investigate the role of N-methyl-D-aspartate receptors (NMDARs) in LHb burst firing.

  • 3

    Spontaneous burst firing in LHb neurons persisted even in the presence of the NMDAR antagonist D-AP5.

  • 4

    Rebound burst firing was also unaffected by D-AP5 and MK-801, suggesting NMDARs are not essential for burst firing.

  • 5

    The findings challenge previous reports that implicated NMDARs in the generation of burst firing in LHb neurons.

Original Source(s)

NMDA receptors are not necessary for burst firing of lateral habenula neurons in mice

  • by Rong Zhou, Jingjing Lu, Yunxiang Ling, Hong Wang, Lijun Cui, Yongliang Pan, Huanxin Chen

  • June 11, 2026

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