Multicenter evaluation of interpretable AI for coronary artery disease diagnosis from PET biomarkers - Takeaways - MDSpire

Multicenter evaluation of interpretable AI for coronary artery disease diagnosis from PET biomarkers

  • By

  • Wenhao Zhang

  • Jacek Kwiecinski

  • Aakash Shanbhag

  • Robert J. H. Miller

  • Shiva Mostafavi

  • Giselle Ramirez

  • Jirong Yi

  • Donghee Han

  • Damini Dey

  • Dominika Grodecka

  • Kajetan Grodecki

  • Mark Lemley

  • Paul Kavanagh

  • Joanna X. Liang

  • Jianhang Zhou

  • Valerie Builoff

  • Jon Hainer

  • Sylvain Carre

  • Leanne Barrett

  • Andrew J. Einstein

  • Stacey Knight

  • Steve Mason

  • Viet T. Le

  • Wanda Acampa

  • Samuel Wopperer

  • Panithaya Chareonthaitawee

  • Daniel S. Berman

  • Marcelo F. Di Carli

  • Piotr J. Slomka

  • January 14, 2026

  • 0 min

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  • 1

    The study developed an AI model that integrates 10 PET MPI parameters to enhance the diagnosis of coronary artery disease (CAD).

  • 2

    The AI model demonstrated superior performance in diagnosing CAD compared to traditional clinical measurements and quantitative thresholds.

  • 3

    The model was validated on a large external cohort, confirming its robustness and generalizability across multiple centers.

  • 4

    Patients with CAD exhibited significantly higher ischemic total perfusion deficit and lower myocardial blood flow compared to those without CAD.

  • 5

    Coronary artery calcium scores were assessed, revealing a substantial proportion of patients with high calcium burden in both training and testing cohorts.

Original Source(s)

Multicenter evaluation of interpretable AI for coronary artery disease diagnosis from PET biomarkers

  • by Wenhao Zhang, Jacek Kwiecinski, Aakash Shanbhag, Robert J. H. Miller, Shiva Mostafavi, Giselle Ramirez, Jirong Yi, Donghee Han, Damini Dey, Dominika Grodecka, Kajetan Grodecki, Mark Lemley, Paul Kavanagh, Joanna X. Liang, Jianhang Zhou, Valerie Builoff, Jon Hainer, Sylvain Carre, Leanne Barrett, Andrew J. Einstein, Stacey Knight, Steve Mason, Viet T. Le, Wanda Acampa, Samuel Wopperer, Panithaya Chareonthaitawee, Daniel S. Berman, Marcelo F. Di Carli, Piotr J. Slomka

  • January 14, 2026

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