Long-term outcomes after resting full-cycle ratio and deferral of revascularization - Takeaways - MDSpire

Long-term outcomes after resting full-cycle ratio and deferral of revascularization

  • By

  • Stephan Nienaber

  • Jakob Wind

  • Philipp Lake

  • Victor Mauri

  • M. Adam

  • Karl Finke

  • Henning Guthoff

  • Stephan Baldus

  • Marcel Halbach

  • Hendrik Wienemann

  • July 7, 2026

  • 0 min

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  • 1

    Coronary artery disease accounts for 35–40% of cardiovascular-related deaths in the EU and US, leading to over 5 million fatalities annually.

  • 2

    Fractional flow reserve (FFR) is the standard for assessing coronary stenoses, but its use is limited due to procedural time, costs, and patient discomfort.

  • 3

    The resting full-cycle ratio (RFR) measures the lowest Pd/Pa ratio throughout the cardiac cycle, potentially improving accuracy in various patient conditions.

  • 4

    This study evaluated clinical outcomes after RFR assessment in 773 patients with deferred revascularization due to angiographically intermediate stenoses.

  • 5

    The primary endpoint was the 2-year incidence of major adverse cardiac events, including cardiovascular death, myocardial infarction, or stroke.

Original Source(s)

Long-term outcomes after resting full-cycle ratio and deferral of revascularization

  • by Stephan Nienaber, Jakob Wind, Philipp Lake, Victor Mauri, M. Adam, Karl Finke, Henning Guthoff, Stephan Baldus, Marcel Halbach, Hendrik Wienemann

  • July 7, 2026

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