Development of a Bone Marrow-on-a-Chip System for Investigating Human Immune Cell Dynamics

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A NIH-funded study developed a bone marrow-on-a-chip model to investigate the dynamics of human immune cells, particularly plasma cells.
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The model integrates a lymphoid organoid and a tissue chip to observe plasma cell migration, maturation, and persistence in bone marrow.
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The research addresses fundamental questions about B cell movement and the role of the bone marrow environment in immune responses.
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The chip's architecture mimics the bone marrow's structural features and biological functions, enabling detailed imaging of plasma cells.
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The system allows for the introduction of patient-derived cells to study aging effects and immune responses in autoimmune and allergic diseases.

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