Diagnostic performance of 18F-FDG PET-CT and SPECT for bone metastases from colorectal cancer: a retrospective study - Takeaways - MDSpire

Diagnostic performance of 18F-FDG PET-CT and SPECT for bone metastases from colorectal cancer: a retrospective study

  • By

  • Fangyi Gong

  • Yu Fang

  • Ting Ge

  • Yuanjin Gong

  • Bo Zhang

  • Baiwen Hu

  • June 12, 2026

  • 0 min

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  • 1

    The study compared the diagnostic performance of 18F-FDG PET-CT and SPECT for detecting bone metastases in colorectal cancer patients.

  • 2

    A total of 118 patients underwent both imaging modalities, revealing 533 abnormal lesions, with 469 confirmed as metastatic.

  • 3

    PET-CT demonstrated a sensitivity of 91.3% and specificity of 93.8%, significantly outperforming SPECT's sensitivity of 59.7% and specificity of 46.9%.

  • 4

    The overall diagnostic accuracy for PET-CT was 91.6%, while SPECT's accuracy was only 58.2%.

  • 5

    The findings suggest that PET-CT is superior for diagnosing bone metastases in colorectal cancer, although SPECT remains a valuable screening tool.

Original Source(s)

Diagnostic performance of 18F-FDG PET-CT and SPECT for bone metastases from colorectal cancer: a retrospective study

  • by Fangyi Gong, Yu Fang, Ting Ge, Yuanjin Gong, Bo Zhang, Baiwen Hu

  • June 12, 2026

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