High levels of cell-free hemoglobin and iron in cerebral thrombi of pre-Omicron COVID-19 stroke patients: novel drivers of SARS-CoV-2–induced prothrombotic state - Takeaways - MDSpire
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Elevated concentrations of cell-free hemoglobin and iron found in cerebral thrombi of stroke patients prior to the Omicron variant: new contributors to the prothrombotic effects of SARS-CoV-2

  • By

  • María Payá

  • Cristian Alcahut-Rodríguez

  • Rosa A. Barbella-Aponte

  • Francisco Hernández-Fernández

  • Juan D. Molina-Nuevo

  • Gemma Barroso-García

  • Beatriz Castro-Robles

  • Susana López-López

  • Lourdes Arias-Salazar

  • Óscar Ayo-Martín

  • Jorge García-García

  • Blanca Yélamos-Sanz

  • Natalia García-Flores

  • Alba G. Arandilla

  • Rafael Moreno-Luna

  • Alicia Aliena-Valero

  • Isabel Vielba-Gómez

  • José I. Tembl

  • Juan B. Salom

  • Gemma Serrano-Heras

  • Tomás Segura

  • August 29, 2026

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  • 1

    SARS-CoV-2 has led to over 777 million infections and 7 million deaths globally since its emergence in December 2019.

  • 2

    COVID-19 increases the risk of cerebrovascular disease, with ischemic stroke occurring in approximately 1.5% of infected individuals pre-Omicron.

  • 3

    COVID-19-related strokes are often cryptogenic, associated with poorer outcomes and higher NIHSS scores compared to non-COVID-19 strokes.

  • 4

    The study investigates cerebral thrombi from COVID-19 patients to identify molecular drivers of the prothrombotic state linked to SARS-CoV-2.

  • 5

    Elevated levels of cell-free hemoglobin and iron were found in cerebral thrombi, suggesting new contributors to the prothrombotic effects of SARS-CoV-2.

Original Source(s)

High levels of cell-free hemoglobin and iron in cerebral thrombi of pre-Omicron COVID-19 stroke patients: novel drivers of SARS-CoV-2–induced prothrombotic state

  • by María Payá, Cristian Alcahut-Rodríguez, Rosa A. Barbella-Aponte, Francisco Hernández-Fernández, Juan D. Molina-Nuevo, Gemma Barroso-García, Beatriz Castro-Robles, Susana López-López, Lourdes Arias-Salazar, Óscar Ayo-Martín, Jorge García-García, Blanca Yélamos-Sanz, Natalia García-Flores, Alba G. Arandilla, Rafael Moreno-Luna, Alicia Aliena-Valero, Isabel Vielba-Gómez, José I. Tembl, Juan B. Salom, Gemma Serrano-Heras, Tomás Segura

  • August 29, 2026

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