Identification of genes associated with cervical intervertebral disc degeneration and immune cell infiltration

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The study identified 71 differentially expressed genes (DEGs) in cervical intervertebral disc degeneration (IDD), including 50 upregulated and 21 downregulated.
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Key diagnostic biomarkers for cervical IDD were identified as CDKN3, SLC22A4, and SYDE1 through machine learning and experimental validation.
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KEGG pathway analysis indicated significant enrichment in inflammation-related pathways associated with cervical IDD.
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Immune infiltration analysis suggested that the identified genes may influence IDD pathogenesis by modulating immune cell populations.
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Quantitative PCR confirmed significant expression changes for CDKN3, SLC22A4, and SYDE1 in cervical IDD specimens compared to controls.

Frontiers In Surgery

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