Pre-Amyloidosis Red-Flag Clinical Diagnoses in Light Chain (AL) Versus Age-Related Transthyretin (ATTRwt) Amyloidosis: Electronic Health Record–Based Descriptive Study - Takeaways - MDSpire

Pre-Amyloidosis Red-Flag Clinical Diagnoses in Light Chain (AL) Versus Age-Related Transthyretin (ATTRwt) Amyloidosis: Electronic Health Record–Based Descriptive Study

  • By

  • Noel Estrada-Merly

  • Liliana E Pezzin

  • Rodney Sparapani

  • Anita D'Souza

  • June 22, 2026

  • 0 min

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  • 1

    Amyloidosis includes light chain (AL) and age-related transthyretin (ATTRwt) types, both causing multiorgan involvement.

  • 2

    Patients with AL amyloidosis are generally younger and have a higher incidence of clonal plasma cell disorders compared to ATTRwt patients.

  • 3

    Heart failure and atrial fibrillation are more prevalent in ATTRwt patients, while renal and gastrointestinal symptoms are more common in AL patients.

  • 4

    The study utilized a large dataset from electronic health records to identify clinical indicators prior to the diagnosis of AL and ATTRwt.

  • 5

    Findings suggest distinct clinical patterns for AL and ATTRwt, highlighting the need for improved recognition of symptoms to reduce diagnostic delays.

Original Source(s)

Pre-Amyloidosis Red-Flag Clinical Diagnoses in Light Chain (AL) Versus Age-Related Transthyretin (ATTRwt) Amyloidosis: Electronic Health Record–Based Descriptive Study

  • by Noel Estrada-Merly, Liliana E Pezzin, Rodney Sparapani, Anita D'Souza

  • June 22, 2026

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