Atypical congenital toxoplasmosis presenting with neonatal jaundice and central nervous system involvement: a case report and therapeutic challenges to limited access to first-line anti-toxoplasma medications - Takeaways - MDSpire

Atypical congenital toxoplasmosis presenting with neonatal jaundice and central nervous system involvement: a case report and therapeutic challenges to limited access to first-line anti-toxoplasma medications

  • By

  • Li Wang

  • Kaiwei Ding

  • Shuai Yu

  • Zheng Guo

  • Yongjiao Wang

  • Lingkong Zeng

  • Wenhao Yuan

  • June 25, 2026

  • 0 min

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  • 1

    Congenital toxoplasmosis can present with isolated neonatal jaundice, which may delay diagnosis and complicate treatment.

  • 2

    A 9-day-old male infant with jaundice was diagnosed with congenital toxoplasmosis after positive serological tests and T. gondii DNA detection.

  • 3

    The infant exhibited subclinical chorioretinitis, cerebral edema, and auditory dysfunction, highlighting the diverse manifestations of congenital toxoplasmosis.

  • 4

    Initial treatment with azithromycin and trimethoprim-sulfamethoxazole showed no improvement, necessitating a switch to standard therapy.

  • 5

    After starting pyrimethamine, sulfadiazine, and folinic acid, the patient showed rapid clinical improvement and resolution of brain lesions.

Original Source(s)

Atypical congenital toxoplasmosis presenting with neonatal jaundice and central nervous system involvement: a case report and therapeutic challenges to limited access to first-line anti-toxoplasma medications

  • by Li Wang, Kaiwei Ding, Shuai Yu, Zheng Guo, Yongjiao Wang, Lingkong Zeng, Wenhao Yuan

  • June 25, 2026

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