Prognostic impact of organ involvement in aggressive adult T-cell leukemia/lymphoma: definition of risk organ and proposal of a prognostic index - Takeaways - MDSpire

Prognostic impact of organ involvement in aggressive adult T-cell leukemia/lymphoma: definition of risk organ and proposal of a prognostic index

  • By

  • Koji Jimbo

  • Ayumu Ito

  • Hirona Ichimura

  • Junichi Kuroda

  • Shohei Andoh

  • Aki Sato

  • Kazuaki Yokoyama

  • Takahiro Fukuda

  • Kaoru Uchimaru

  • Yasuhito Nannya

  • October 16, 2025

  • 0 min

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  • 1

    Adult T-cell leukemia/lymphoma (ATL) has a poor prognosis, particularly in aggressive forms requiring intensive systemic therapy.

  • 2

    Advanced clinical stage is common in aggressive ATL, with over 90% of cases reported at stage III or IV.

  • 3

    Organ involvement, especially in the lung, liver, and CNS, significantly impacts overall survival in aggressive ATL patients.

  • 4

    A prognostic index was proposed, identifying lung, liver, and CNS as risk organs that predict poor outcomes in aggressive ATL.

  • 5

    The number of involved organs correlates with overall survival, with worse outcomes observed in patients with more organ lesions.

Original Source(s)

Prognostic impact of organ involvement in aggressive adult T-cell leukemia/lymphoma: definition of risk organ and proposal of a prognostic index

  • by Koji Jimbo, Ayumu Ito, Hirona Ichimura, Junichi Kuroda, Shohei Andoh, Aki Sato, Kazuaki Yokoyama, Takahiro Fukuda, Kaoru Uchimaru, Yasuhito Nannya

  • October 16, 2025

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