Research progress on the etiology and pathogenesis of pancreatic cancer: a narrative review - Takeaways - MDSpire

Research progress on the etiology and pathogenesis of pancreatic cancer: a narrative review

  • By

  • Meitong Guo

  • Qi Han

  • Zixi Wang

  • Dong Ya

  • Xiaoyan Wang

  • June 11, 2026

  • 0 min

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  • 1

    Pancreatic cancer (PC) has a high mortality rate and is the sixth leading cause of cancer-related deaths globally.

  • 2

    Current treatment strategies for PC, including surgery and chemotherapy, have not significantly improved patient survival rates.

  • 3

    The etiology of PC involves environmental factors, genetic susceptibility, and diseases like diabetes and chronic pancreatitis.

  • 4

    Precancerous lesions such as PanIN, IPMN, and MCN play a crucial role in the progression of pancreatic ductal adenocarcinoma.

  • 5

    KRAS mutations are among the earliest molecular events in PC, with other genetic alterations occurring at later stages.

Original Source(s)

Research progress on the etiology and pathogenesis of pancreatic cancer: a narrative review

  • by Meitong Guo, Qi Han, Zixi Wang, Dong Ya, Xiaoyan Wang

  • June 11, 2026

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