Biochanin A attenuates doxorubicin-induced cardiotoxicity in rats with associated modulation of PI3K/Akt/mTOR and p38 MAPK signaling - Takeaways - MDSpire

Biochanin A attenuates doxorubicin-induced cardiotoxicity in rats with associated modulation of PI3K/Akt/mTOR and p38 MAPK signaling

  • By

  • Mashael M. AlMutairi

  • Huda M. AlKreathy

  • Rasheed A. Shaik

  • Amani E. Alharbi

  • Rania Magadmi

  • July 7, 2026

  • 0 min

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  • 1

    Doxorubicin (DOX) is an effective chemotherapy agent but is limited by dose-dependent cardiotoxicity.

  • 2

    Biochanin A (BCA) has antioxidant and anti-inflammatory properties that may mitigate DOX-induced cardiac injury.

  • 3

    In the study, BCA treatment improved ECG parameters and reduced serum cardiac biomarkers in DOX-treated rats.

  • 4

    BCA administration was associated with decreased oxidative stress, inflammation, and apoptosis in cardiac tissue.

  • 5

    The cardioprotective effects of BCA were linked to modulation of the PI3K/Akt/mTOR and p38 MAPK signaling pathways.

Original Source(s)

Biochanin A attenuates doxorubicin-induced cardiotoxicity in rats with associated modulation of PI3K/Akt/mTOR and p38 MAPK signaling

  • by Mashael M. AlMutairi, Huda M. AlKreathy, Rasheed A. Shaik, Amani E. Alharbi, Rania Magadmi

  • July 7, 2026

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