Digging deeper into NINJ1: its multifaceted role in central nervous system diseases

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NINJ1 is a cell-surface molecule that mediates plasma membrane rupture across various lytic cell death pathways.
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NINJ1 plays a dual role in CNS disorders by executing lytic cell death and regulating neuroinflammatory cell trafficking.
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Recent structural biology advances have revealed NINJ1's three-dimensional architecture and its autoinhibitory mechanisms.
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NINJ1 is implicated in multiple CNS disorders, including multiple sclerosis, ischemic stroke, and neurodegenerative diseases.
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Therapeutic strategies targeting NINJ1, such as monoclonal antibodies and small-molecule inhibitors, show potential in neurological diseases.

Frontiers In Immunology

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