A nomogram for predicting free flap necrosis in soft tissue reconstruction of lower limbs: a retrospective cohort study - Takeaways - MDSpire

A nomogram for predicting free flap necrosis in soft tissue reconstruction of lower limbs: a retrospective cohort study

  • By

  • Cong Cheng

  • Xiaoyu Huang

  • Hai Liang

  • Zongyuan Jiang

  • May 26, 2026

  • 0 min

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  • 1

    A retrospective cohort study identified five independent risk factors for free flap necrosis in lower limb soft tissue reconstruction.

  • 2

    The identified risk factors include Gustilo-Anderson classification IIIB/IIIC, preoperative D-dimer > 0.5 mg/L, and preoperative albumin < 35 g/L.

  • 3

    The developed nomogram demonstrated an optimism-corrected AUC of 0.87 in the training cohort, indicating strong discriminative ability.

  • 4

    The nomogram showed excellent calibration and clinical utility, outperforming 'treat all' or 'treat none' strategies in decision curve analysis.

  • 5

    Further prospective external validation in multi-center settings is needed to confirm the nomogram's generalizability and real-world clinical utility.

Original Source(s)

A nomogram for predicting free flap necrosis in soft tissue reconstruction of lower limbs: a retrospective cohort study

  • by Cong Cheng, Xiaoyu Huang, Hai Liang, Zongyuan Jiang

  • May 26, 2026

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