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Aqueous cytology may diagnose iris metastasis without biopsy

Aqueous humor sampling confirmed iris metastasis in a patient with refractory secondary glaucoma and lung adenocarcinoma, avoiding iris tissue sampling.

  • By

  • Andrea Surnit

  • September 29, 2026

  • 3 min

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  • 1

    Aqueous humor cytology may diagnose iris metastasis from lung adenocarcinoma without tissue biopsy in selected patients.

  • 2

    A 56-year-old male with EGFR-mutated lung adenocarcinoma presented with decreased vision and elevated intraocular pressure.

  • 3

    Cytologic findings from aqueous humor indicated Class V, consistent with metastatic adenocarcinoma, confirming iris metastasis.

  • 4

    The patient experienced multiple complications, including secondary glaucoma and progressive iris tumors, ultimately leading to death.

  • 5

    Negative cytology results do not exclude metastatic disease; repeat sampling and biopsy may be necessary if suspicion remains high.

Original Source(s)

Aqueous cytology may diagnose iris metastasis without biopsy

  • by Andrea Surnit

  • September 29, 2026

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