Seeking a viable perioperative preemptive analgesia regimen: a prospective, randomized, controlled, double-blind superiority study of intravenous acetaminophen in children undergoing adenotonsillectomy - Takeaways - MDSpire

Seeking a viable perioperative preemptive analgesia regimen: a prospective, randomized, controlled, double-blind superiority study of intravenous acetaminophen in children undergoing adenotonsillectomy

  • By

  • Zugang Yi

  • Runxin Qiu

  • Qianyi Qiu

  • Yiyi Li

  • Xinyan Gan

  • Xiang Li

  • Fang Chen

  • June 23, 2026

  • 0 min

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  • 1

    The study evaluated the efficacy and safety of preoperative intravenous acetaminophen in preschool children undergoing adenotonsillectomy.

  • 2

    Eighty children aged 3–6 years were randomly assigned to receive either acetaminophen or saline prior to anesthetic induction.

  • 3

    Results showed significantly lower FLACC pain scores at 1 hour post-extubation in the acetaminophen group compared to placebo.

  • 4

    PACU opioid rescue rates were reduced in the acetaminophen group, indicating a decrease in opioid requirements post-surgery.

  • 5

    No significant differences were found in emergence delirium scores, home analgesia use, or adverse events within 24 hours.

Original Source(s)

Seeking a viable perioperative preemptive analgesia regimen: a prospective, randomized, controlled, double-blind superiority study of intravenous acetaminophen in children undergoing adenotonsillectomy

  • by Zugang Yi, Runxin Qiu, Qianyi Qiu, Yiyi Li, Xinyan Gan, Xiang Li, Fang Chen

  • June 23, 2026

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