Efficacy and safety of tumor treating fields (TTF) combined with chemotherapy versus chemotherapy only in the treatment of glioblastoma: a systematic review and meta-analysis - Takeaways - MDSpire

Efficacy and safety of tumor treating fields (TTF) combined with chemotherapy versus chemotherapy only in the treatment of glioblastoma: a systematic review and meta-analysis

  • By

  • Naibijiang Abuliezi

  • Yihan Sun

  • Jiale Zhao

  • Xinge Qu

  • Yanyan Wu

  • Tiantian Liao

  • Gulinuer Kuerban

  • Xiaoyi Dun

  • Qinfen Wu

  • May 8, 2026

  • 0 min

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  • 1

    Tumor treating fields (TTF) combined with chemotherapy significantly improves progression-free and overall survival in glioblastoma patients.

  • 2

    The systematic review analyzed 14 studies involving 2,376 glioblastoma patients, including randomized and observational trials.

  • 3

    No significant difference in systemic adverse events was found between TTF and chemotherapy alone, but skin irritation was more common with TTF.

  • 4

    TTF demonstrates a favorable safety profile with minimal systemic toxicity, making it a promising adjunct therapy for glioblastoma.

  • 5

    The findings underscore the need for more effective treatment modalities for glioblastoma, given the limited survival rates with current therapies.

Original Source(s)

Efficacy and safety of tumor treating fields (TTF) combined with chemotherapy versus chemotherapy only in the treatment of glioblastoma: a systematic review and meta-analysis

  • by Naibijiang Abuliezi, Yihan Sun, Jiale Zhao, Xinge Qu, Yanyan Wu, Tiantian Liao, Gulinuer Kuerban, Xiaoyi Dun, Qinfen Wu

  • May 8, 2026

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