Case Report: Cardiac metastasis from urothelial carcinoma with predominant squamous differentiation in a young woman: first reported case treated with enfortumab vedotin plus pembrolizumab

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Cardiac metastases from urothelial carcinoma are rare and associated with poor prognosis, particularly in young patients.
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A 36-year-old woman with muscle-invasive bladder cancer presented with a large right ventricular mass requiring urgent surgical intervention.
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The cardiac lesion exhibited a pure squamous phenotype, indicating aggressive tumor biology and a potential clonal selection.
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Postoperative treatment with enfortumab vedotin and pembrolizumab was initiated, but the patient experienced rapid deterioration.
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This case highlights the challenges of managing squamous-dominant metastatic urothelial carcinoma with cardiac involvement.

Frontiers In Oncology

by Alix Vansteeger, El Mamoune El Ghali Benlemlih, Antoine Delmarche, Stéphane Thiry, Hélène Dano, Justine Castaigne, Vassiliki Pasoglou, Sandy Van Nieuwenhove, Bernhard Gerber, Gaby Aphram, Qaid Ahmed Shagera, Christophe Beauloye, Rachel Galot, Cédric van Marcke, Emmanuel Seront
May 20, 2026

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