The Pick fold in tau filaments from human MAPT mutants - Takeaways - MDSpire

The Pick fold in tau filaments from human MAPT mutants

  • By

  • Chao Qi

  • Sofia Lövestam

  • Jenny Shi

  • Alexey G. Murzin

  • Sew Peak-Chew

  • Thomas T. Warner

  • Harro Seelaar

  • Patrick W. Cullinane

  • Zane Jaunmuktane

  • John C. van Swieten

  • Sjors H. W. Scheres

  • Michel Goedert

  • July 8, 2026

  • 0 min

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  • 1

    Six tau isoforms are expressed from the MAPT gene in the human brain, differing by the inclusion of specific exons.

  • 2

    MAPT mutations lead to frontotemporal dementia and parkinsonism, influencing tau filament formation and splicing.

  • 3

    Cryo-EM structures of tau filaments from FTDP-17 T individuals with specific MAPT mutations reveal distinct tau folds.

  • 4

    The D252V and ΔG389-I392 mutations result in tau filaments with a single protofilament identical to the Pick fold.

  • 5

    Mass spectrometric analysis shows co-assembly of wild-type and mutant tau in filaments with the Pick fold.

Original Source(s)

The Pick fold in tau filaments from human MAPT mutants

  • by Chao Qi, Sofia Lövestam, Jenny Shi, Alexey G. Murzin, Sew Peak-Chew, Thomas T. Warner, Harro Seelaar, Patrick W. Cullinane, Zane Jaunmuktane, John C. van Swieten, Sjors H. W. Scheres, Michel Goedert

  • July 8, 2026

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