Metagenomic Characterization of Gut Microbiota in Rheumatoid Arthritis-Associated Interstitial Lung Disease: Taxonomic Shifts and Clinical Correlations - Takeaways - MDSpire
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Metagenomic Analysis of Gut Microbiota in Patients with Interstitial Lung Disease Linked to Rheumatoid Arthritis: Taxonomic Changes and Clinical Associations

  • By

  • Fan, Ran

  • Zang, Qifeng

  • Xu, Yan

  • Gao, Ling

  • Zhou, Jun

  • Zang, Yinshan

  • May 28, 2026

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  • 1

    RA-ILD patients exhibit specific gut microbial alterations, including enrichment of Escherichia/Shigella and depletion of Roseburia and Ruminococcus.

  • 2

    Alpha and beta diversity of gut microbiota did not significantly differ among RA-ILD patients, RA-non-ILD patients, and healthy controls.

  • 3

    Pro-inflammatory genera positively correlated with disease activity, while butyrate-producing genera showed a negative correlation.

  • 4

    Co-occurrence network analysis indicated that RA patients have a more complex microbial network compared to healthy controls and RA-ILD patients.

  • 5

    The study suggests that gut microbiota changes may play a role in RA-ILD pathogenesis through the gut-lung axis, warranting further investigation.

Original Source(s)

Metagenomic Characterization of Gut Microbiota in Rheumatoid Arthritis-Associated Interstitial Lung Disease: Taxonomic Shifts and Clinical Correlations

  • by Fan, Ran , Zang, Qifeng , Xu, Yan , Gao, Ling , Zhou, Jun , Zang, Yinshan

  • May 28, 2026

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