False-positive beta-glucan test due to beta-glucan component in sterile gauze during treatment of fungal sepsis: a case report - Takeaways - MDSpire

False-positive beta-glucan test due to beta-glucan component in sterile gauze during treatment of fungal sepsis: a case report

  • By

  • Yi Wu

  • Da Ma

  • Qiling Lin

  • ChunLei Zhang

  • May 18, 2026

  • 0 min

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  • 1

    The (1,3)-β-D-glucan (BDG) assay, known as the G test, is prone to false-positive results, complicating the diagnosis of invasive fungal diseases.

  • 2

    A patient with fungal sepsis showed positive G test results for three months despite negative blood cultures, attributed to contamination from sterile gauze.

  • 3

    The patient's clinical condition improved with antifungal treatment, highlighting the need for careful interpretation of G test results.

  • 4

    Medical sterile gauze and similar materials contain significant BDG levels, which can lead to misleading G test outcomes.

  • 5

    Thorough evaluation of G test results is essential when microbiological evidence is lacking, to avoid misdiagnosis and inappropriate treatment.

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